It  is a statin medication, used to prevent cardiovascular & cerebrovascular disease in those at high risk and elevated serum lipids.  It is recommended to be used together with dietary changes, exercise, and weight loss.It is taken orally.

Drug interactions

The following drugs can have negative interactions with rosuvastatin and should be discussed with the prescribing doctor:

• Coumarin anticoagulants(‘blood thinners’, e.g. warfarin) can affect the removal of rosuvastatin
• Ciclosporin, colchicine
• Drugs that may decrease the levels or activity of endogenous steroid hormones, e.g. cimetidine, ketoconazole, and spironolactone
• Additional medications for high cholesterol such as clofibrate, fenofibrate, gemfibrozil, and niacin(when taken in lipid-modifying doses of 1 g/day and above)
• Specific protease inhibitorsincluding atazanavir (when taken with ritonavir), lopinavir/ritonavir and simeprevir
• Aluminum and magnesium hydroxide antacids should not be taken within two hours of taking rosuvastatin
• Coadministration of rosuvastatin with eluxadolinemay increase the risk of rhabdomyolysis and myopathy

Medical uses

The primary use of rosuvastatin is for prevention of cardiovascular disease in those at high risk and the treatment of abnormally elevated lipids.

Mechanism of action

Rosuvastatin is a competitive inhibitor of the enzyme HMG-CoA reductase, having a mechanism of action similar to that of other statins.
Putative beneficial effects of rosuvastatin therapy on chronic heart failure may be negated by increases in collagen turnover markers as well as a reduction in plasma coenzyme Q10levels in patients with chronic heart failure.